11^th Annual Conference on Stem Cell and Regenerative Medicine

Stem cells involves in  physiologic systems that express the outcome of developmental events and organismal stress, as these cells play a fundamental role of tissue maintenance and repair, the received signals will play a critical role in the integrity of the organism. Mostly focused is shown on stem cell identification and the molecular pathways involved in their regulation. Achievement of physiologically responsive stem cell functions is done by these pathways. The following information will help in understanding the stem cells in the context of their microenvironment regarding the relation between stem cell niche dysfunction, carcinogenesis and aging. The stem cells both reside and receive stimuli that determine their fate as stem cell niche is the in vivo microenvironment. Neither niche should not be considered simply a physical location for stem cells, nor as the place where extrinsic signals interact and integrate to influence stem cell behaviour. Stimuli includes cell-to-cel

Researchers from the University of Birmingham have found a way to successfully mimic the body’s natural healing process. Using cell derived nano-sized particles called vesicles; the scientists were able to repair the damaged tissue. According to the researchers this new technique will have the potential to repair, bone, teeth and cartilage. Dr Sophie Cox, from the School of Chemical Engineering at the University, said: “Though it may never fully mimic the complexity of vesicles produced by cells in nature, this work portrays an unused pathway tackling characteristic formative forms to encourage difficult tissue repair.” The researchers’ solution delivers the advantages of cell-based therapies but without using viable cells, through using the regenerative capacity of extracellular vesicles naturally generated during bone formation. In-vitro testing revealed that if these vesicles were applied in combination with a simple phosphate, it outperforms the current gold standard BMP-2.