11^th Annual Conference on Stem Cell and Regenerative Medicine

Cartilage-Hair Hypoplasia One of the rarest genetic disease is Cartilage-Hair Hypoplasia characterisation characteristically, it lead to skeletal deformities and a weak immune system. It also affects in short stature (dwarfism) Primary alopecia condition is been generated by the disease having no pigment by the light fine hair. 15% of people are affected by this condition. Symptoms include: fine, sparse hair and eyebrows skeletal and spinal abnormalities short limb dwarfism anaemia low levels of white blood cells The inherited autosomal recessive is Cartilage-Hair Hypoplasia. Its means that this disease is been carried by both parents but generally no sign of it is been shown by their own. By uniparental disomy it can be inherited but in rare cases. That means instead of inheriting one copy from each parent the child inherits copies two chromosome from only one parent. In Amish or Finnish population, the Cartilage-Hair Hypoplasia is been seen the most. Both male

How Cancer Persists Stem cells are found in numerous tissues in the body, its life span is limited unlike with all other regular cells. They have the ability of dividing and renovate themselves for long time period. There unspecialized character justifies that ensuring cells convert into different cell type on time when one cell divides. Like, stem cells inside the bone marrow have ability of becoming bone. Fat and blood cells Likewise, there is believed that cancer stem cell is present in the main part of tumour, in the other hand there growth is also undefined and ability of self-renovate till they convert into new cancer cells. The major tumours treatment leaves cancer stem cell unmarked. Cancer stem cell can move undetectably even after treatment of major tumours effectively to the blood stream by the immune system to generate new tumours. This process is known as metastasis. These minor tumours become more aggressive year after and it’s really difficult to treat them.

Spinal cord consist of class of neuron named as sensory interneurons, this neurons plays the lead role in communicating information between parts of body and central nervous system, through which sense of touch is been enabled. Paralyzed people are seriously affected by the lack of touch. Scientists added a precise bone morphogenetic protein named as BMP4, and retinoic acid which is another signalling molecule, containing two type of mixture of sensory interneurons towards human embryonic stem cell i.e. sense that body is in space is a proprioception is given by DI 1 sensory interneurons on the other side DI3 sensory interneurons assist tem for feeling sense of pressure To convincing pluripotent stem cell the scientists found duplicate mixture of sensory interneurons which established while adding similar signalling molecules, this are formed by reprogramming the mature cells (skin cells) of patients. The method of reprogramming has ability of creating any cell type with main