STEM CELLS AND THEIR NICHES

Stem cells involves in  physiologic systems that express the outcome of developmental events and organismal stress, as these cells play a fundamental role of tissue maintenance and repair, the received signals will play a critical role in the integrity of the organism. Mostly focused is shown on stem cell identification and the molecular pathways involved in their regulation. Achievement of physiologically responsive stem cell functions is done by these pathways. The following information will help in understanding the stem cells in the context of their microenvironment regarding the relation between stem cell niche dysfunction, carcinogenesis and aging.
The stem cells both reside and receive stimuli that determine their fate as stem cell niche is the in vivo microenvironment. Neither niche should not be considered simply a physical location for stem cells, nor as the place where extrinsic signals interact and integrate to influence stem cell behaviour. Stimuli includes cell-to-cell and cell-matrix interactions and signals (molecules) that activate and/or repress genes and transcription programs. Stem cells are maintained in a dormant state, because of the direct consequence of this interaction which leads to induced self-renewal or commit to a more differentiated state.
Hypothesis of a specialized stem cell microenvironment was first postulated in 1978 by Schoefield. He revealed that niches have a defined anatomical location and removal of stem cells from their niche results in differentiation. Drosophila melanogaster and Caenorhabditis elegans gonads invertebrate model was first used in the demonstration and characterization of niche components. Examination of these systems, characterized in less complex animals, has led to pivotal insights into understanding the more complex mammalian niche architecture. It shows that the fundamental anatomical components and molecular pathways of the niche environment are highly conserved among species, although their respective roles within the niche may show distinct variations. Hence, it was proved that it is possible to identify common niche components that are associated with similar functions.
Major tracks summoned are Stem Cell Biology, Regenerative Medicine, Bioprocessing & Bio Banking, Stem Cell Niche, Tissue Regeneration, Embryonic Stem cell, Stem Cell Transplantation, Patient Specific Drug Discovery, Biomedicine, Adult Stem Cell, Stem Cell Biomarkers, Rehabilitation Engineering, Stem Cells for Organ Repair, Genetically modified Stem Cell Therapy, Cancer Stem Cell, and 3D Bioprinting & Biofabrication.

For further more updates on the availing research proficiency, do visit: https://stemcell-regenerative.conferenceseries.com/abstract-submission.php


For details about the webpage, go through the link provided; PS: https://stemcell-regenerative.conferenceseries.com/

Comments

Post a Comment

Popular posts from this blog

Do Stem Cells act as Anti-Cancer Vaccines?

Image
Induced Pluripotent Stem Cells iPSC are originated from skin or blood cells that have been reprogrammed back into an embryonic like pluripotent cells that enables the increase of an unlimited source of any type of human cell needed for therapeutic purposes. iPS cells plays an important role in regenerative medicine. They can become many different types of cells and tissues that can help in damage repair due to trauma or disease. Recent study shows that the iPS cells training the immune system to attack or even prevent tumours.  Ten years ago, adult cells were genetically reprogrammed to behave like pluripotent stem cells. To produce the vaccine for cancer, the researchers turned to induced pluripotent stem cells.  The main aim of the study is to vaccinate a person with his or her own iPS cells to protect against the development of many types of cancer. The iPS cells mimic Anti-Cancer vaccine because, since the cancer cells resemble immature progenitor cells, which ar
Read more

Cancer stem cells

Image
How Cancer Persists Stem cells are found in numerous tissues in the body, its life span is limited unlike with all other regular cells. They have the ability of dividing and renovate themselves for long time period. There unspecialized character justifies that ensuring cells convert into different cell type on time when one cell divides. Like, stem cells inside the bone marrow have ability of becoming bone. Fat and blood cells Likewise, there is believed that cancer stem cell is present in the main part of tumour, in the other hand there growth is also undefined and ability of self-renovate till they convert into new cancer cells. The major tumours treatment leaves cancer stem cell unmarked. Cancer stem cell can move undetectably even after treatment of major tumours effectively to the blood stream by the immune system to generate new tumours. This process is known as metastasis. These minor tumours become more aggressive year after and it’s really difficult to treat them.
Read more

RESEARCH AND TRANSPLANT OF STEM CELL

Image
Regenerative Medicine is used to Replace tissues and Organs which are been damaged by disease. It also helpful for the permanent damaged organs. This can be done through the cell based therapy or by using cell products. Most of the regenerative medicine is depend upon the endogenous developmental or repair process and stem cell plays a main role in regenerative medicine. And they are integral part of the Regenerative Medicine. The ability of stem cell is currently being researched by the doctors and scientists it can cure untreatable diseases like diabetes, heart failure stem cell also important in drug testing .These are used in Joints, Muscle pain, Ligaments. Regenerative Injection Treatment are using autologous platelet or plasma or bone marrow Tissue engineer is the branch of regenerative medicine. Cells are building block of tissues and Tissues are the main function in the body .Tissue engineering and Regenerative Medicine is the regeneration of cells and tissues and b
Read more