Is there any End to Huntington’s disease?


Huntington’s disease is a fatal genetic disorder that causes the tolerant breakdown of nerve cells in the brain. It deteriorates a person’s physical and mental abilities during their prime working years and has no cure. Nowadays there are approximately 30,000 suggestive Americans and more than 200,000 at-risk of causing the disease.

Symptoms the initial age is 30 to 50 and it gets chronic in the period between 10 to 25 year. Ultimately, the weakened individual causes to pneumonia, heart failure or other complications. Everyone has the gene that causes Huntington’s disease, but only Huntington’s disease and possibly pass it on to upcoming those that inherit the expansion of the gene will get the generation.

Symptoms Include:

Personality changes, mood swings & depression
Forgetfulness & impaired judgment
Unsteady gait & involuntary movements (chorea)
Slurred speech, difficulty in swallowing & significant weight loss

Who Is At Risk

Every child of a parent with Huntington’s disease has a 50/50 chance of receiving the expanded gene that causes the disease. If the child has not inherited this expanded gene, he or she will never develop the disease and cannot pass it on to their children.






Research

For the first time ,A system to model embryonic  stem cell have been developed by scientist  by introducing  early abnormalities in the way Huntington’s neurons look, and how these cells form larger structures that had not previously been associated with the disease.
Huntington’s is straight frontward genetic culprit diseases. Total hundred percent of people having mutated Huntington (HTT) form of the gene for developing the diseases. Extra DNA is taken by mutation to produce longer protein then usual protein by the gene
Researchers hope that these new cells will be a further useful for studying the cellular and molecular convolutions of Huntington’s disease and suggested a new model  for humans which will be further useful for the brain and other diseases
                 

Comments

Post a Comment

Popular posts from this blog

Do Stem Cells act as Anti-Cancer Vaccines?

Image
Induced Pluripotent Stem Cells iPSC are originated from skin or blood cells that have been reprogrammed back into an embryonic like pluripotent cells that enables the increase of an unlimited source of any type of human cell needed for therapeutic purposes. iPS cells plays an important role in regenerative medicine. They can become many different types of cells and tissues that can help in damage repair due to trauma or disease. Recent study shows that the iPS cells training the immune system to attack or even prevent tumours.  Ten years ago, adult cells were genetically reprogrammed to behave like pluripotent stem cells. To produce the vaccine for cancer, the researchers turned to induced pluripotent stem cells.  The main aim of the study is to vaccinate a person with his or her own iPS cells to protect against the development of many types of cancer. The iPS cells mimic Anti-Cancer vaccine because, since the cancer cells resemble immature progenitor cells, which ar
Read more

Cancer stem cells

Image
How Cancer Persists Stem cells are found in numerous tissues in the body, its life span is limited unlike with all other regular cells. They have the ability of dividing and renovate themselves for long time period. There unspecialized character justifies that ensuring cells convert into different cell type on time when one cell divides. Like, stem cells inside the bone marrow have ability of becoming bone. Fat and blood cells Likewise, there is believed that cancer stem cell is present in the main part of tumour, in the other hand there growth is also undefined and ability of self-renovate till they convert into new cancer cells. The major tumours treatment leaves cancer stem cell unmarked. Cancer stem cell can move undetectably even after treatment of major tumours effectively to the blood stream by the immune system to generate new tumours. This process is known as metastasis. These minor tumours become more aggressive year after and it’s really difficult to treat them.
Read more

RESEARCH AND TRANSPLANT OF STEM CELL

Image
Regenerative Medicine is used to Replace tissues and Organs which are been damaged by disease. It also helpful for the permanent damaged organs. This can be done through the cell based therapy or by using cell products. Most of the regenerative medicine is depend upon the endogenous developmental or repair process and stem cell plays a main role in regenerative medicine. And they are integral part of the Regenerative Medicine. The ability of stem cell is currently being researched by the doctors and scientists it can cure untreatable diseases like diabetes, heart failure stem cell also important in drug testing .These are used in Joints, Muscle pain, Ligaments. Regenerative Injection Treatment are using autologous platelet or plasma or bone marrow Tissue engineer is the branch of regenerative medicine. Cells are building block of tissues and Tissues are the main function in the body .Tissue engineering and Regenerative Medicine is the regeneration of cells and tissues and b
Read more