Are Histone acts as a key for male Fertility?



 Histone

Histones have emerged as key players in the regulation of gene expression. However, that PTMs can directly impact chromatin it has been suggested that PTMs of core histones (H2A, H2B, H3, and H4) have the potential to govern chromatin function according to the so-called “histone code” hypothesis by recruiting specific binding proteins.

combinations of histone marks at promoters and enhancers correlate with the developmental potential and fate of cells.10,11 In undifferentiated embryonic stem cells (ESCs), pluripotency maintenance genes (e.g., Nanog, Oct4, and Sox2) are marked with high levels of H3K4 methylation at their transcriptional start sites.


Research

Histones are basic proteins that confer order and structure to DNA and it plays an important role in gene regulation and earlier Researchers have identified that histone BigH1 acts as a key protein in stem cell differentiation to male sex cells. 






Role of histone H1 in male infertility

All animals contain the histone that is specific to the germline. In Drosophila, BigH1 is stated as male and female germ lines and histone BigH1 shows most difference to the germline variant of human females as well as some similarities to variants of the male germ line

Histones as regulators in stem cell differentiation into tissue cells

Histones play an important role in differentiation of stem cells including all the cells of an organism like skin, intestinal, lung, and any other type. Whereas during the differentiation of female sex cells from the BigH1, we know that histone is most essential, but we assume it will have a distinct role since the process involving female sex cells is considerably different to that of male ones.


For more details : https://stemcell-regenerative.conferenceseries.com/

Email : stemregenerative@geneticconferences.com


















Comments

Post a Comment

Popular posts from this blog

Do Stem Cells act as Anti-Cancer Vaccines?

Image
Induced Pluripotent Stem Cells iPSC are originated from skin or blood cells that have been reprogrammed back into an embryonic like pluripotent cells that enables the increase of an unlimited source of any type of human cell needed for therapeutic purposes. iPS cells plays an important role in regenerative medicine. They can become many different types of cells and tissues that can help in damage repair due to trauma or disease. Recent study shows that the iPS cells training the immune system to attack or even prevent tumours.  Ten years ago, adult cells were genetically reprogrammed to behave like pluripotent stem cells. To produce the vaccine for cancer, the researchers turned to induced pluripotent stem cells.  The main aim of the study is to vaccinate a person with his or her own iPS cells to protect against the development of many types of cancer. The iPS cells mimic Anti-Cancer vaccine because, since the cancer cells resemble immature progenitor cells, which ar
Read more

Cancer stem cells

Image
How Cancer Persists Stem cells are found in numerous tissues in the body, its life span is limited unlike with all other regular cells. They have the ability of dividing and renovate themselves for long time period. There unspecialized character justifies that ensuring cells convert into different cell type on time when one cell divides. Like, stem cells inside the bone marrow have ability of becoming bone. Fat and blood cells Likewise, there is believed that cancer stem cell is present in the main part of tumour, in the other hand there growth is also undefined and ability of self-renovate till they convert into new cancer cells. The major tumours treatment leaves cancer stem cell unmarked. Cancer stem cell can move undetectably even after treatment of major tumours effectively to the blood stream by the immune system to generate new tumours. This process is known as metastasis. These minor tumours become more aggressive year after and it’s really difficult to treat them.
Read more

RESEARCH AND TRANSPLANT OF STEM CELL

Image
Regenerative Medicine is used to Replace tissues and Organs which are been damaged by disease. It also helpful for the permanent damaged organs. This can be done through the cell based therapy or by using cell products. Most of the regenerative medicine is depend upon the endogenous developmental or repair process and stem cell plays a main role in regenerative medicine. And they are integral part of the Regenerative Medicine. The ability of stem cell is currently being researched by the doctors and scientists it can cure untreatable diseases like diabetes, heart failure stem cell also important in drug testing .These are used in Joints, Muscle pain, Ligaments. Regenerative Injection Treatment are using autologous platelet or plasma or bone marrow Tissue engineer is the branch of regenerative medicine. Cells are building block of tissues and Tissues are the main function in the body .Tissue engineering and Regenerative Medicine is the regeneration of cells and tissues and b
Read more