Are Histone acts as a key for male Fertility?



 Histone

Histones have emerged as key players in the regulation of gene expression. However, that PTMs can directly impact chromatin it has been suggested that PTMs of core histones (H2A, H2B, H3, and H4) have the potential to govern chromatin function according to the so-called “histone code” hypothesis by recruiting specific binding proteins.

combinations of histone marks at promoters and enhancers correlate with the developmental potential and fate of cells.10,11 In undifferentiated embryonic stem cells (ESCs), pluripotency maintenance genes (e.g., Nanog, Oct4, and Sox2) are marked with high levels of H3K4 methylation at their transcriptional start sites.


Research

Histones are basic proteins that confer order and structure to DNA and it plays an important role in gene regulation and earlier Researchers have identified that histone BigH1 acts as a key protein in stem cell differentiation to male sex cells. 






Role of histone H1 in male infertility

All animals contain the histone that is specific to the germline. In Drosophila, BigH1 is stated as male and female germ lines and histone BigH1 shows most difference to the germline variant of human females as well as some similarities to variants of the male germ line

Histones as regulators in stem cell differentiation into tissue cells

Histones play an important role in differentiation of stem cells including all the cells of an organism like skin, intestinal, lung, and any other type. Whereas during the differentiation of female sex cells from the BigH1, we know that histone is most essential, but we assume it will have a distinct role since the process involving female sex cells is considerably different to that of male ones.


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