Development of kidney progenitor cells toward regenerative medicine

Kidney not only produce urine but also plays major role in blood pressure control, that’s why it’s an important organ for living , if it get damaged or lost functionality it no longer regenerated. The main functional unit of Kidney is glomeruli and tubules, which are generated from Kidney progenitor cell during fetal life. The major reason why kidney cannot be able to regenerate is because the progenitor cell are lost before or soon after kidney development completes

Researchers reported that with the help of human iPS cell nephrons can be prepared, although for regenerative medicine, precursor cells are required in large amount. Scientists tried for culturing kidney progenitor cells but the problem is that they are not preserved for more than three days.
Between 1 to 20 days of culturing the progenitor cells recollect their function and grow up to 1800 times. Generally In vivo this cells disappears within 10 days. Although scientists using there technique through which they can recollect in double amount within same time. Moreover, the upsurge in the total quantity of cells is somehow 100 times the quantity usually present within body.
For retaining the ability to form glomeruli and tubules advanced experiments where done through culture technique by the help of iPS cells to derive kidney progenitor cells which stemmed in four times the total quantity of cells over within 8th day. This discovery, a culture technique that upsurges kidney progenitor cells though upholding glomerulus-formation ability.
For constructing an organ a huge number of cells are essential in regenerative medicine. The achievement of this research in determining a culture way that artificially upturns both the amount of kidney progenitor cells and their capability time is a chief growth for the field. The finding is anticipated to help in the search for causes of kidney disease, new drug development, and other cellular research.
For omitting the 14 day duration it would be the best cryopreservation for kidney progenitor cells if conceivable.

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