Pancreatic progenitor cells


What is pancreatic stem cell?

Pancreatic progenitor cells are stem cells originating from the developing fore gut endoderm which have potential of differentiating into lineage specific progenitors, thus liable for the pancreas development. Giving rise to exocrine as well as endocrine cells. Acinar cells are being established from exocrine cells. The Beta cell makes insulin, glucagon is secreted form alpha cells, somatostatin is secreted form delta cell while pancreatic polypeptide is secreted by PP-cells.

Pancreatic stem cells have ability of regenerating beta cells

It has been confirmed by the researchers that human pancreas contain progenitor cells stimulates by developing into glucose responsive beta cells. Thus, researchers are finding way towards rising regenerative cell therapies for type 1 diabetes patients. This will be a major challenge that stands in the way of inventing biological treatment for the disease.
For the decades it has been postulated that pancreas harbours progenitor cell has ability of regenerating islets, but not conclusively demonstrated. Scientists at the Diabetes Research Institute at the University of Miami Miller School of Medicine is being pinpointing the precise anatomic location of stem cells & validate their proliferative ability of turning into glucose-responsive beta cells.
The capability of offering regenerative medicine approaches to refurbish production of insulin within native pancreas would help in replacing the necessity for transplantation of insulin forming cells. Avoiding immune destructiveness annulment of autoimmunity in insulin forming cells which is been form newly could be required by type 1 diabetes. For this purpose, currently, efforts are congregating on immune tolerance which can induce without the help of anti-rejection drug for whole life.

Related Scientists
Dr Camillo Ricordi, Dr Juan Dominguez-Bendala, Dr Ricardo Pastori
Diabetes Research Institute


for details: https://stemcell-regenerative.conferenceseries.com/


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