11^th Annual Conference on Stem Cell and Regenerative Medicine

Kidney not only produce urine but also plays major role in blood pressure control, that’s why it’s an important organ for living , if it get damaged or lost functionality it no longer regenerated. The main functional unit of Kidney is glomeruli and tubules , which are generated from Kidney progenitor cell during fetal life. The major reason why kidney cannot be able to regenerate is because the progenitor cell are lost before or soon after kidney development completes Researchers reported that with the help of human iPS cell nephrons can be prepared, although for regenerative medicine, precursor cells are required in large amount. Scientists tried for culturing kidney progenitor cells but the problem is that they are not preserved for more than three days. Between 1 to 20 days of culturing the progenitor cells recollect their function and grow up to 1800 times. Generally In vivo this cells disappears within 10 days. Although scientists using there technique through which

What is pancreatic stem cell ? Pancreatic progenitor cells are stem cells originating from the developing fore gut endoderm which have potential of differentiating into lineage specific progenitors, thus liable for the  pancreas development. Giving rise to exocrine as well as endocrine cells. Acinar cells are being established from exocrine cells. The Beta cell makes insulin, glucagon is secreted form alpha cells, somatostatin is secreted form delta cell while pancreatic polypeptide is secreted by PP-cells. Pancreatic stem cells have ability of regenerating beta cells It has been confirmed by the researchers that human pancreas contain progenitor cells stimulates by developing into glucose responsive beta cells. Thus, researchers are finding way towards rising regenerative cell therapies for type 1 diabetes patients. This will be a major challenge that stands in the way of inventing biological treatment for the disease. For the decades it has been postulated that

           Can Multiple Sclerosis be treated by Neural Stem Cells? Multiple sclerosis Multiple sclerosis is an autoimmune disease in which the body's immune system attacks its own tissues and disables the Brain and Spinal cord. And this immune system malfunction destroys myelin. It isn't clear why MS develops in some people and not others. A combination of genetics and environmental factors appears to be responsible. Symptoms Signs and symptoms of multiple sclerosis may vary from person to person and over the course of the disease depending on the location of affected nerve fibers. ·          Numbness or weakness in one or more limbs that typically occurs on one side of your body at     a time, or the legs and trunk ·          Prolonged double vision ·          Pain in parts of of your body ·         Electric-shock sensations that occur with certain neck movements, especially bending the        neck forward ·          Tremor, lac

Are Histone acts as a key for male Fertility?  Histone Histones have emerged as key players in the regulation of gene expression. However, that PTMs can directly impact chromatin it has been suggested that PTMs of core histones (H2A, H2B, H3, and H4) have the potential to govern chromatin function according to the so-called “histone code” hypothesis by recruiting specific binding proteins. combinations of histone marks at promoters and enhancers correlate with the developmental potential and fate of cells.10,11 In undifferentiated embryonic stem cells (ESCs), pluripotency maintenance genes (e.g., Nanog, Oct4, and Sox2) are marked with high levels of H3K4 methylation at their transcriptional start sites. Research Histones are basic proteins that confer order and structure to DNA and it plays an important role in gene regulation and earlier Researchers have identified that histone BigH1 acts as a key protein in stem cell differentiation to male sex cells.

                   Is there any End to Huntington’s disease? Huntington’s disease is a fatal genetic disorder that causes the tolerant breakdown of nerve cells in the brain. It deteriorates a person’s physical and mental abilities during their prime working years and has no cure. Nowadays there are approximately 30,000 suggestive Americans and more than 200,000 at-risk of causing the disease. Symptoms the initial age is 30 to 50 and it gets chronic in the period between 10 to 25 year. Ultimately, the weakened individual causes to pneumonia, heart failure or other complications. Everyone has the gene that causes Huntington’s disease, but only Huntington’s disease and possibly pass it on to upcoming those that inherit the expansion of the gene will get the generation. Symptoms Include: Personality changes, mood swings & depression Forgetfulness & impaired judgment Unsteady gait & involuntary movements (chorea) Slurred speech, difficulty in swallowin

Are Stem cells and Regenerative medicine living up to their promises? Stem cells are taken from a donor and put them into a patient to treat a disease or injury. Regenerative medicine makes use of cells, bio materials, and molecules to fix structures in the body that do not function properly due to disease or injury. However, however today the treatments of regenerative medicine are very low. However Cell therapies and regenerative medicine improve the health of patients with their potential representing a structural shift in healthcare by focusing on the causes of disease by repairing, replacing, or regenerating damaged cells in the body.                                                                                                 Early successes The earlier day’s cell therapy was done by the transfusion of blood, which is common in clinical trials nowadays. It is also used in case of severe burn and scald injuries by using their own cells when a pati

                          Research and Transplants on adult stem cells Adult Stem cell is a broad type of stem cells, Latest research of adult stem cells has been fueled  by their abilities to divide and generate all the cell types of the organ from which they originate potentially regenerating the entire organ from a few cells. There are no such controversial issues with scientific researches for the use of adult stem cells, unlike the embryonic stem cells. Unlike embryonic stem cells, the use of adult stem cells in research and therapy is not controversial because the production of adult stem cells does not require the destruction of an embryo. Adult stem cell transplants are already widely used to treat dozens of conditions in patients There are nearly 3,500 on-going or completed clinical trials (in patients) using adult stem cells, as listed in the National Institutes of Health/FDA-approved database. Already by 2007, there were at least 73 condi